FIRAZYR® (Icatibant Injection)

FIRAZYR® is a brand-name medication that contains the active ingredient icatibant. It is used to treat acute attacks of hereditary angioedema (HAE), a rare genetic disorder characterized by episodes of severe swelling in various body parts. FIRAZYR® is a bradykinin B2 receptor antagonist. It works by blocking the effects of bradykinin, a peptide that is responsible for the swelling and discomfort associated with HAE attacks.

Indications and Uses

FIRAZYR® is indicated for the following purposes:

• Acute treatment of hereditary angioedema (HAE) attacks in adults with C1-esterase inhibitor deficiency.

• It is used to relieve and shorten the duration of HAE attacks.

Dosage and Administration

The dosage of FIRAZYR® is determined by a healthcare provider and is individualized based on the patient's specific needs. The medication is administered through a subcutaneous injection, typically into the abdominal area. Patients are trained on how to self-administer FIRAZYR®.

Contraindications

FIRAZYR® should not be used in individuals with known hypersensitivity to icatibant or any of its components. It is essential to discuss any allergies or potential reactions with a healthcare provider.

Adverse Effects and Side Effects

Common side effects of FIRAZYR® may include:

• Injection site reactions, such as pain, redness, and swelling.

• Fever.

• Dizziness.

• Headache.

• Nausea.

Serious side effects are rare but may include:

• Anaphylactic reactions, which can manifest as hives, difficulty breathing, and swelling of the face, lips, or tongue.

• Increased risk of heart attack and other cardiovascular events in patients with underlying heart disease.

• It is crucial to report any side effects, especially serious or unusual ones, to your healthcare provider.

Storage and Shelf Life

Store FIRAZYR® at room temperature (20-25°C or 68-77°F). Protect it from excessive heat. Do not use FIRAZYR® after the expiration date.

Packaging and Presentation

FIRAZYR® is available as a sterile solution for subcutaneous injection in pre-filled syringes.

Regulatory Information

FIRAZYR® is subject to regulation by health authorities to ensure its safety and efficacy. It is essential to use this medication as directed by a healthcare professional and in accordance with local regulations.

References

Always consult with your healthcare provider and refer to the official prescribing information and product labeling for the most up-to-date and comprehensive information on FIRAZYR®. Your healthcare provider will guide you in the proper use of this medication, monitor your progress, and tailor the treatment to your specific medical condition.