Duetact (Pioglitazone and Glimepiride)

Duetact is a medication that combines two active ingredients, pioglitazone and glimepiride. It is primarily used to treat type 2 diabetes mellitus. Duetact is a combination medication that belongs to the thiazolidinedione (pioglitazone) and sulfonylurea (glimepiride) classes of drugs. Pioglitazone works by improving insulin sensitivity, while glimepiride stimulates the pancreas to produce more insulin. This combination helps lower blood sugar levels in people with type 2 diabetes.

Indications and Uses

Duetact is prescribed for the following purposes:

• Treatment of type 2 diabetes mellitus to improve glycemic control.

• It is often used in combination with diet and exercise.

• It is not suitable for the treatment of type 1 diabetes or diabetic ketoacidosis.

Dosage and Administration:

The dosage of Duetact may vary depending on the patient's specific needs and response to the medication. Duetact is taken orally, typically once daily with the first meal of the day. The dosing is individualized, and healthcare providers may adjust the dose as needed.

Contraindications

Duetact should not be used in individuals with:

Known hypersensitivity to pioglitazone, glimepiride, or any of its components.

• Type 1 diabetes.

• Diabetic ketoacidosis.

• Severe heart failure or a history of heart failure.

• Severe hepatic impairment.

It is essential to discuss your medical history and any allergies with a healthcare provider.

Adverse Effects and Side Effects

Common side effects of Duetact may include:

• Hypoglycemia (low blood sugar), which can manifest as shakiness, sweating, dizziness, or confusion.

• Weight gain.

• Edema (swelling).

• Headache.

• Increased risk of upper respiratory tract infection.

Serious side effects are rare but may include:

• Liver problems, which can manifest as yellowing of the skin or eyes, dark urine, or abdominal pain.

• Heart failure symptoms, such as shortness of breath and swelling.

• Hemolytic anemia, a decrease in red blood cell count.

It is crucial to report any severe or unusual side effects to your healthcare provider.

Storage and Shelf Life:

Store Duetact at room temperature (15-30°C or 59-86°F). Protect it from excessive heat, moisture, and light. Do not use Duetact after the expiration date.

Packaging and Presentation

Duetact is available in tablet form with various strengths and quantities.

Regulatory Information

Duetact is subject to regulation by health authorities to ensure its safety and efficacy. It is essential to use this medication as directed by a healthcare professional and in accordance with local regulations.

References

Always consult with your healthcare provider and refer to the official prescribing information and product labeling for the most up-to-date and comprehensive information on Duetact. Your healthcare provider will guide you in the proper use of this medication, monitor your progress, and tailor the treatment to your specific medical condition.