CINRYZE® (C1 Esterase Inhibitor)

CINRYZE® is a brand-name medication that contains C1 Esterase Inhibitor [Human]. It is a specialized blood product used in the treatment of hereditary angioedema (HAE), a rare genetic disorder characterized by recurrent and potentially life-threatening swelling of various body parts. CINRYZE® is a concentrated form of human C1 esterase inhibitor, a protein found in the blood. It is used to replace deficient or nonfunctional C1 esterase inhibitor in individuals with hereditary angioedema. This deficiency can lead to uncontrolled activation of certain pathways, resulting in excessive swelling.

Indications and Uses: CINRYZE® is indicated for the following purposes:

• Prophylactic (preventive) treatment to reduce the frequency and severity of hereditary angioedema (HAE) attacks.

• It is used to replace missing or deficient C1 esterase inhibitor, which helps regulate the biochemical pathways involved in HAE.

Dosage and Administration:

The dosage of CINRYZE® is individualized based on the patient's specific C1 esterase inhibitor levels, clinical condition, and response to treatment. The medication is administered intravenously. The dose and frequency of administration are determined by a healthcare provider and may vary based on the patient's needs.

Contraindications

CINRYZE® should not be used in individuals with known hypersensitivity to human C1 esterase inhibitor or any of its components. It is essential to discuss any allergies or potential reactions with a healthcare provider.

Adverse Effects and Side Effects

Adverse effects with CINRYZE® are rare but may include:

• Allergic reactions, which can manifest as hives, difficulty breathing, and swelling of the face, lips, or tongue.

• Thrombotic events, which may include blood clots in the veins. These are generally more common in patients with underlying risk factors.

It is crucial to report any adverse effects or unusual reactions to your healthcare provider.

Storage and Shelf Life

Store CINRYZE® at room temperature (2-25°C or 36-77°F). Protect it from freezing and excessive heat. Do not use CINRYZE® after the expiration date.

Packaging and Presentation

CINRYZE® is available in vials for intravenous administration.

Regulatory Information

CINRYZE® is subject to regulation by health authorities to ensure its safety and efficacy. It is essential to use this medication as directed by a healthcare professional and in accordance with local regulations.

References

Always consult with your healthcare provider and refer to the official prescribing information and product labeling for the most up-to-date and comprehensive information on CINRYZE®. Your healthcare provider will guide you in the proper use of this medication, monitor your progress, and tailor the treatment to your specific medical condition.